When Daniel Pevear first got into anti-microbial drug discovery in the late 1980s ‘people believed that we had so many great antibiotics that the war against pathogenic bacteria may have been won’, he says. He was working in the antibacterial research team of the now-defunct pharma company Sterling Winthrop in […]
« Back-to-school » season means buying pens and paper, figuring out the new bus route, and … earaches. Doctors typically treat these infections with antibiotics, but children don’t always complete the full course, accelerating resistance to these medications. Today, researchers report developing a single-use nanoscale system that’s unlikely to generate resistance. Using […]
A new analysis shows that infectious bacteria exposed to the antibiotic albicidin rapidly develop up to a 1,000-fold increase in resistance via a gene amplification mechanism. Mareike Saathoff of Freie Universität Berlin, Germany, and colleagues present these findings August 10 in the open access journal PLOS Biology. Bacterial resistance to […]
A scientific journey decades in the making at Duke University has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections (UTIs). The synthetic molecule works fast and is durable in animal tests. It works by interfering with […]
The antibiotic cefazolin is an essential drug according to the World Health Organization (WHO). It is usually produced via batch manufacturing, but this multistep process is time-consuming, wasteful and requires very specialized facilities. Now for the first-time, researchers have manufactured cefazolin using the continuous-flow method. This method is cheaper, quicker, […]
In children with suspected sinusitis, a nasal swab to test for three types of bacteria can tell whether antibiotics are likely to be effective or not, according to a new JAMA study by researchers at the University of Pittsburgh and UPMC. « Five million kids in the U.S. get prescribed antibiotics […]
